Optochemical control of transcription by the use of 7-deaza-adenosine-based diarylethenes
Simon M. Büllmann, Theresa Kolmar, Philip Slawetzky, Simon Wald, Andres Jäschke
Abstract
Out of nine different 7-deaza-adenosine diarylethenes, we identified a high-performance photoswitch, suitable for the synthesis of photochromic DNA. By using solid phase synthesis, a photoresponsive T7 promotor was generated which allowed reversibly modulating the rate of enzymatic RNA synthesis in vitro.
Topics & Concepts
PhotoswitchPhotochromismAdenosineChemistryTranscription (linguistics)Combinatorial chemistryPhotochemistryBiochemistryLinguisticsPhilosophyPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchPorphyrin and Phthalocyanine Chemistry