Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size
Sherazaan D. Ismail, Catherine Riou, Sarah Joseph, Nancie M. Archin, David M. Margolis, Alan S. Perelson, Tyler Cassidy, Melissa-Rose Abrahams, Matthew Moeser, Lyle R. McKinnon, Farzana Osman, Quarraisha Abdool Karim, Salim S. Abdool Karim, Ronald Swanstrom, Carolyn Williamson, Nigel Garrett, Wendy A. Burgers
Abstract
Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.
Topics & Concepts
MedicineHuman immunodeficiency virus (HIV)Antiretroviral therapyCD8ImmunologyVirologyViral replicationNadirImmunopathologyCD4-CD8 RatioVirusViral loadSidaViral diseaseImmune systemLymphocyte subsetsEngineeringSatelliteAerospace engineeringHIV Research and TreatmentHIV/AIDS Research and InterventionsHIV/AIDS drug development and treatment