The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF- <i>κ</i> B
Jumana Khalil, Shintaro Yamada, Yuta Tsukamoto, Hiroto Abe, Masayuki Shimojima, Hiroki Kato, Takashi Fujita
Abstract
) mice. These findings establish the essential role of NSs in SFTS pathogenesis and suggest NF-κB as a possible therapeutic target.
Topics & Concepts
Cytokine stormBiologyChemokineCytokineProinflammatory cytokineInterferonImmunologyNF-κBInflammationMedicineDiseasePathologyInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)Viral Infections and VectorsViral Infections and Outbreaks ResearchVector-Borne Animal Diseases