The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
Wiwin Is Effendi, Tatsuya Nagano
Abstract
The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.
Topics & Concepts
HedgehogHedgehog signaling pathwayIdiopathic pulmonary fibrosisSonic hedgehogFibrosisBiologySignal transductionPulmonary fibrosisCancer researchTranscription factorCell biologyCell growthPathologyMedicineLungGeneticsInternal medicineGeneHedgehog Signaling Pathway StudiesTumors and Oncological CasesCancer Diagnosis and Treatment