Catalytic Asymmetric Allylic Amination with Isatins, Sulfonamides, Imides, Amines, and <i>N</i>-Heterocycles
Ciarán C. Lynch, Kaluvu Balaraman, Christian Wolf
Abstract
A generally useful palladium-catalyzed method for the asymmetric allylic amination with a large variety of isatins, sulfonamides, imides, amines, and N-heterocycles is introduced. A single protocol with a readily available catalyst accomplishes this reaction at room temperature with high yields and enantioselectivities often exceeding 90%, which is demonstrated with 31 examples.
Topics & Concepts
AminationChemistryAllylic rearrangementCatalysisPalladiumOrganic chemistryCombinatorial chemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods