Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands
Hanqiao Xu, Takashi Kurohara, Nobumichi Ohoka, Genichiro Tsuji, Takao Inoué, Mikihiko Naito, Yosuke Demizu
Topics & Concepts
ChemistryLinkerSolid-phase synthesisUbiquitin ligaseCombinatorial chemistryLigand (biochemistry)CereblonBromodomainAlkylStereochemistryUbiquitinBiochemistryOrganic chemistryDNAReceptorGeneHistoneComputer scienceOperating systemPeptideProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments