Down-regulation miR-146a-5p in Schwann cell-derived exosomes induced macrophage M1 polarization by impairing the inhibition on TRAF6/NF-κB pathway after peripheral nerve injury
Jun Sun, Zhi Liao, Zhangyu Li, Hao Li, Zhimin Wu, Chuan Chen, Hui Wang
Topics & Concepts
MicrovesiclesMacrophage polarizationSchwann cellNeuroscienceMacrophagePeripheralCell biologyNF-κBPeripheral nerve injuryPeripheral nervemicroRNAChemistryMedicineBiologySignal transductionAnatomyInternal medicineGeneIn vitroBiochemistryNerve injury and regenerationPain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms