Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
Aliza P. Wingo, Yue Liu, Ekaterina S. Gerasimov, Jake Gockley, Benjamin A. Logsdon, Duc M. Duong, Eric B. Dammer, Chloe Robins, Thomas G. Beach, Eric M. Reiman, Michael P. Epstein, Philip L. De Jager, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo
Topics & Concepts
Genome-wide association studyBiologyMendelian randomizationProteomeGenetic associationPathogenesisDiseaseGeneticsComputational biologyExpression quantitative trait lociHuman genomeApolipoprotein EGeneGenomeBioinformaticsSingle-nucleotide polymorphismMedicineGenetic variantsGenotypeImmunologyPathologyGenetic Associations and EpidemiologyBioinformatics and Genomic NetworksEpigenetics and DNA Methylation