Molecular Oxygen-Mediated Radical Alkylation of C(sp<sup>3</sup>)–H Bonds with Boronic Acids
Le Yang, Zhihong Qiu, Jintao Wu, Jianyou Zhao, Tong Shen, Xuan Huang, Zhong‐Quan Liu
Abstract
)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinates and amines together with alkylboronic acids under an oxygen atmosphere, a variety of unnatural α-amino acids and peptides could be obtained in good yields.
Topics & Concepts
ChemistryAlkylationBoronic acidMolecular oxygenOxygenMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques