I<sub>2</sub>/TBHP mediated diastereoselective synthesis of spiroaziridines
K. T. Ashitha, Puthiya Purayil Vinaya, A. Siva Krishna, Deepthy Cheeran Vincent, Renjitha Jalaja, Sunil Varughese, Sasidhar B. Somappa
Abstract
Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.
Topics & Concepts
ChemistryAlkylCombinatorial chemistryPrimary (astronomy)Organic chemistryPhysicsAstronomySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods