Oncolytic vesicular stomatitis virus–based cellular vaccine improves triple-negative breast cancer outcome by enhancing natural killer and CD8<sup>+</sup> T-cell functionality
Seyedeh-Raheleh Niavarani, Christine Lawson, Marie Boudaud, Camille Simard, Lee‐Hwa Tai
Abstract
The occurrence of triple-negative breast cancer (TNBC) is significant, with an estimated 40,000 cases diagnosed in US women each year (American Cancer Society, 2018). TNBC is a vastly heterogeneous disease that are grouped together histologically since they lack hormone and Her-2 receptors. However
Topics & Concepts
Vesicular stomatitis virusOncolytic virusTriple-negative breast cancerBreast cancerMedicineCD8OncologyCancerCancer researchInternal medicineVirusImmunologyImmune systemVirus-based gene therapy researchCAR-T cell therapy researchImmunotherapy and Immune Responses