The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions
Han Wu, Yu Sun, Wee Lin Wong, Jiajia Cui, Jingyang Li, Xuefu You, Lee Fah Yap, Yu Huang, Wei Hong, Xinyi Yang, Ian C. Paterson, Hao Wang
Topics & Concepts
Signal transductionR-SMADTransforming growth factorChemistryCell biologyTGF beta receptor 2ReceptorPhosphorylationCell signalingEpithelial–mesenchymal transitionCancer researchTGF alphaGrowth factorBiologyBiochemistryDownregulation and upregulationGeneTGF-β signaling in diseasesCancer Cells and MetastasisMetabolism, Diabetes, and Cancer