Phosphoregulation of Rad51/Rad52 by CDK1 functions as a molecular switch for cell cycle–specific activation of homologous recombination
Gyubum Lim, Yeonji Chang, Won‐Ki Huh
Abstract
/M phase cyclins. Nonphosphorylatable mutations in Rad51 and Rad52 impair the DNA binding affinity of Rad51 and the affinity between Rad52 rings that leads to their interaction. Collectively, our data provide detailed insights into the regulatory mechanism of cell cycle-dependent homologous recombination activation in eukaryotic cells.
Topics & Concepts
RAD51RAD52Homologous recombinationHomologous chromosomeCyclin-dependent kinase 1Cell biologyRecombinationBiologyChemistryGeneticsCell cycleCellDNAGeneDNA Repair MechanismsCRISPR and Genetic EngineeringMitochondrial Function and Pathology