Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors
Mukul Prasad, Sashigala Ponnalagu, Qun Zeng, Khang Luu, Si Min Lang, Hiu Yi Wong, Man Cheng, Meihui Wu, Karthik Mallilankaraman, Radoslaw M. Sobota, Yan Ting Lim, Loo Chien Wang, Chuan Keng Goh, Kai Xun Joshua Tay, Kwok Seng Loh, Cheng‐I Wang, Wen-Hsien Lee, Boon Cher Goh, Chwee Ming Lim, Herbert Schwarz
Topics & Concepts
CD137Immune systemEctopic expressionNasopharyngeal carcinomaCancer researchBiologyAntigenChimeric antigen receptorImmunotherapyImmunologyMedicineCell cultureInternal medicineRadiation therapyGeneticsCAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses