DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan
Topics & Concepts
GPX4Dihydroorotate dehydrogenaseLipid peroxidationCancer cellMitochondrionProgrammed cell deathCell biologyCancer researchChemistryBiologyBiochemistryCancerApoptosisSuperoxide dismutaseOxidative stressEnzymeGlutathione peroxidaseGeneticsFerroptosis and cancer prognosisCancer, Hypoxia, and MetabolismRNA modifications and cancer