Synthesis and Biological Evaluation of Quinoline‐Based Novel Aurones
Gourav Kumar, Ekta Lathwal, Bhavna Saroha, Sanjeev Kumar, Sanjeev Kumar, Suresh Kumar, Suresh Kumar, Nar Singh Chauhan, Tarun Kumar
Abstract
Abstract A new series of quinoline based aurones 7(a–n) has been synthesized and evaluated for their antibacterial, antifungal and antiquorum sensing activities. These novel aurones have been prepared directly from 2‐chloro‐1‐(2,4‐dihydroxyphenyl)ethan‐1‐one in one pot, by reacting it with differently substituted 2‐chloroquinoline‐3‐carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures of these novel aurones are in agreement with their IR, 1 H‐NMR, 13 C‐NMR and HRMS data. Some of these compounds have attributed a significant antiquorum sensing activity.
Topics & Concepts
QuinolineChemistryAntifungalOrganic chemistryCombinatorial chemistryComputational chemistryMedicineDermatologySynthesis of Organic CompoundsMulticomponent Synthesis of HeterocyclesBioactive Compounds and Antitumor Agents