Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches
Bwalya A. Witika, Pedzisai A. Makoni, Scott Kaba Matafwali, Billy Chabalenge, Chiluba Mwila, Aubrey Chichonyi Kalungia, Christian Isalomboto Nkanga, Alain M. Bapolisi, Roderick B. Walker
Abstract
Nanoencapsulation is an approach to circumvent shortcomings such as reduced bioavailability, undesirable side effects, frequent dosing and unpleasant organoleptic properties of conventional drug delivery systems. The process of nanoencapsulation involves the use of biomaterials such as surfactants and/or polymers, often in combination with charge inducers and/or ligands for targeting. The biomaterials selected for nanoencapsulation processes must be as biocompatible as possible. The type(s) of biomaterials used for different nanoencapsulation approaches are highlighted and their use and applicability with regard to haemo- and, histocompatibility, cytotoxicity, genotoxicity and carcinogenesis are discussed.