Novel 3,4-diaminothieno[2,3-b]thiophene-2,5-dicarbohydrazide-based scaffolds as EGFRWT, EGFRT790M, and tubulin polymerization inhibitors with anti-proliferative activity
Moustafa O. Aboelez, Mahmoud Abd El Aleem Ali Ali El‐Remaily, Moumen S. Kamel, Omkulthom Al kamaly, Wael A. A. Fadaly, Mohamed T. M. Nemr, Hend A. A. Ezelarab
Topics & Concepts
ChemistryTubulinMicrotubule polymerizationGefitinibIC50MTT assayStereochemistryIn vitroPharmacologyBiochemistryEpidermal growth factor receptorMicrotubuleReceptorBiologyCell biologyQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsCancer therapeutics and mechanisms