Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF
Génesis Osorio-Toribio, Miriam de J. Velásquez‐Hernández, Paulo G. M. Mileo, J. Antonio Zárate, Javier Águila-Rosas, Gerardo Leyva‐Gómez, Roberto Sánchez‐Sánchez, Jonathan J. Magaña, Mario Alberto Pérez-Díaz, Isabel Abánades Lázaro, Ross S. Forgan, Guillaume Maurin, Enrique Lima, Ilich A. Ibarra
Abstract
The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).