Sub-acute toxicity study of methanol extract of Tetrorchidium didymostemon leaves using biochemical analyses and gene expression in Wistar rats
Osamudiamen Ebohon, Francis Irabor, Ehimwenma Sheena Omoregie
Abstract
leaves extract is relatively safe. However, there is need for caution due to the observed changes in hematological profile, up-regulation of KIM-1 genes as well as down regulation of albumin gene.
Topics & Concepts
MalondialdehydeAspartate transaminaseAlbuminAlanine transaminaseCreatinineSuperoxide dismutaseOxidative stressToxicityNephrotoxicityPharmacologyKidneyChemistryCatalaseEndocrinologyInternal medicineBiochemistryBiologyMedicineAlkaline phosphataseEnzymeDrug-Induced Hepatotoxicity and ProtectionEthnobotanical and Medicinal Plants StudiesNatural Antidiabetic Agents Studies