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Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, Noelle V. Frey, Saar Gill, Alison W. Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E Ambrose, Megan M. Davis, Joseph A. Fraietta, Jennifer L. Brogdon, Regina M. Young, Anne Chew, Bruce L. Levine, Donald L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F. Lacey, Kai Tan, Carl H. June

2022Nature921 citationsDOIOpen Access PDF

Topics & Concepts

Cytotoxic T cellImmunologyChimeric antigen receptorPopulationAdoptive cell transferCD8T cellBiologyAntigenCancer researchCD19MedicineImmune systemGeneticsIn vitroEnvironmental healthCAR-T cell therapy researchImmune Cell Function and InteractionSilicon Carbide Semiconductor Technologies
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells | Litcius