Acetate attenuates perioperative neurocognitive disorders in aged mice
Cen Wen, Tao Xie, Ke Pan, Yu Deng, Zhijia Zhao, Na Li, Jinjun Bian, Xiaoming Deng, Yanping Zha
Abstract
. Acetate suppressed inflammation in lipopolysaccharide-treated BV2 microglial cells, but not when GPR43 was silenced. These results suggest that acetate may bind to GPR43, thereby inhibiting microglial activity, suppressing neuroinflammation, and preventing memory deficits. This makes acetate is a promising therapeutic for surgery-induced neurocognitive disorders and neuroinflammation.
Topics & Concepts
NeuroinflammationNeurocognitiveMicrogliaMedicineMorris water navigation taskProinflammatory cytokinePerioperativePharmacologyInflammationEndocrinologyAnesthesiaInternal medicineHippocampusPsychiatryCognitionIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchNeuroinflammation and Neurodegeneration Mechanisms