Formulation and Evaluation of Azithromycin-Loaded Niosomal Gel: Optimization, In Vitro Studies, Rheological Characterization, and Cytotoxicity Study
Ahlam Zaid Alkilani, Rania Hamed, Hajer Abdo, Lubna Swellmeen, Haneen A. Basheer, Walaa Wahdan, Amani D. Abu Kwiak
Abstract
< 0.001) drug release in the same duration (1.25 ± 0.12%). Overall, these results indicate that niosomal gel could be an effective transdermal nanocarrier for enhancing the permeability of AZM, a BCS class III drug. In conclusion, this study suggests that transdermal formulations of AZM in the niosomal gel were successfully developed and could be used as an alternative route of administration.
Topics & Concepts
AzithromycinCytotoxicityRheologyIn vitroCharacterization (materials science)ChemistryChromatographyMaterials scienceNanotechnologyComposite materialBiochemistryAntibioticsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery Systems