NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses
Camila Oliveira Silva Souza, Natália Ketelut-Carneiro, Cristiane M. Milanezi, Lúcia Helena Faccioli, Luiz Gustavo Gardinassi, João S. Silva
Abstract
T cell responses and enhancing mortality of mice. These findings demonstrate that NLRC4 promotes disease by regulating the production of inflammatory cytokines and cellular responses that depend on the NLRP3 inflammasome activity.
Topics & Concepts
InflammasomeNLRC4EffectorParacoccidioides brasiliensisMicrobiologyCell biologyBiologyImmunologyInflammationCaspase 1Inflammasome and immune disordersFungal Infections and StudiesStreptococcal Infections and Treatments