Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against <i>Streptococcus suis</i> Serotypes 2, 3, 9 and 14**
Shuo Zhang, Mauro Sella, Julinton Sianturi, Patricia Priegue, Dacheng Shen, Peter H. Seeberger
Abstract
Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.
Topics & Concepts
GlycoconjugateSerotypeMicrobiologyAntigenOligosaccharideStreptococcus suisVirologyBiologyImmunologyVirulenceBioinformaticsGeneBiochemistryStreptococcal Infections and TreatmentsMicrobial infections and disease researchAntimicrobial Resistance in Staphylococcus