Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Lovelace J. Luquette, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Yifan Zhao, Hu Jin, D. Gulhan, Javier Ganz, Sara Bizzotto, Samantha L. Kirkham, Tino Hochepied, Claude Libert, Alon Galor, Junho Kim, Michael A. Lodato, Juan I. Garaycoechea, Charles Gawad, Jay West, Christopher A. Walsh, Peter J. Park
Topics & Concepts
IndelBiologyGeneticsINDEL MutationSomatic cellPoint mutationGenomeDNA sequencingHuman genomeMutationGeneComputational biologyWhole genome sequencingSingle-nucleotide polymorphismGenotypeSingle-cell and spatial transcriptomicsCancer Genomics and DiagnosticsCRISPR and Genetic Engineering