Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles
Luyao Li, Bo Zhu, Huihui Fan, Zhiyong Jiang, Junbiao Chang
Abstract
Herein, we report a chiral bifunctional thiourea catalyzed asymmetric Michael addition reaction between 2-(trifluoromethyl)oxazol-5(2<italic>H</italic>)-one as a direct C-2-position nucleophile to 4-nitro-5-styrylisoxazoles for the first time.
Topics & Concepts
ChemistryNucleophileBifunctionalNitroThioureaHemiaminalMichael reactionOrganocatalysisSquaramideTrifluoromethylMedicinal chemistryOrganic chemistryCatalysisEnantioselective synthesisAlkylFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisAsymmetric Synthesis and Catalysis