Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis
Guanfeng Lu, Sheng-Cai Chen, Yuanpeng Xia, Zi‐Ming Ye, Fei Cao, Bo Hu
Abstract
) were synergistically reduced when cGAS was inhibited. Furthermore, cGAS inhibition significantly inhibited RAW264.7 macrophage M1 polarization. These results demonstrate that cGAS may contribute to the development of atherosclerosis through synergistic inflammatory signaling of TLRs, STAT/IRF as well as IFNs, leading to macrophage M1 polarization.
Topics & Concepts
InflammationCell biologySignal transductionChemistryBiologyImmunologyinterferon and immune responsesAtherosclerosis and Cardiovascular DiseasesInflammasome and immune disorders