Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals
Zi‐Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk‐Woo Chan, Kelvin Kai‐Wang To, Honglin Chen, Zhiwei Chen, Kwok‐Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong‐Yan Jin
Topics & Concepts
ImmunogenicityVirologyAttenuated vaccineNasal administrationImmunityBiologyImmune systemNeutralizing antibodyImmunologyAntibodyVirusGeneVirulenceBiochemistrySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral gastroenteritis research and epidemiology