Copper-Catalyzed Three-Component Alkene Carbofunctionalization: C–N, C–O, and C–C Bond Formation from a Single Reaction Platform
Travis L. Buchanan, Samuel N. Gockel, Alexander M. Veatch, Ya‐Nong Wang, Kami L. Hull
Abstract
A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of γ-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol.
Topics & Concepts
ChemistryAlkeneCatalysisIntermolecular forceOlefin fiberNucleophileElectrophileComponent (thermodynamics)Combinatorial chemistryCopperMedicinal chemistryOrganic chemistryMoleculeThermodynamicsPhysicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions