Highly Porous 3D Ni-MOFs as an Efficient and Enzyme-Mimic Electrochemical Sensing Platform for Glucose in Real Samples of Sweat and Saliva in Biomedical Applications
Rajaji Pavadai, Mani Arivazhagan, Jaroon Jakmunee, Pavadai Nethaji, Revathi Palanisamy, Ganesha Honnu, Sutasinee Kityakarn, Jeerawan Khumphon, Chaisak Issro, Dusadee Khamboonrueang, Sirikanjana Thongmee
Abstract
High Resolution Image Download MS PowerPoint Slide Nickel-based metal–organic frameworks, denoted as three-dimensional nickel trimesic acid frameworks (3D Ni-TMAF), are gaining significant attention for their application in nonenzymatic glucose sensing due to their unique properties. Ni-MOFs possess a high surface area, tunable pore structures, and excellent electrochemical activity, which makes them ideal for facilitating electron transfer and enhancing the catalytic oxidation of glucose. This research describes a new electrochemical enzyme-mimic glucose biosensor in biological solutions that utilizes 3D nanospheres Ni-TMAF created layer-by-layer on a highly porous nickel substrate. The Ni-TMAF based on the nonenzymatic electrochemical glucose oxidation represent the promising approach, leveraging the unique properties of Ni-TMAF to provide efficient, stable, and potentially more cost-effective alternatives to traditional enzyme-mimic sensors. The MOF is synthesized from trimesic acid (TMA) and nickel nitrate hexahydrate through a solvothermal reaction process. The resulting Ni-TMAF utilizes the three-dimensional nanospheres of crystalline porous structure with a large surface area and numerous active sites for catalytic reaction toward glucose. Ni-TMAF are indeed known for their excellent electrocatalytic activity, particularly in the context of glucose oxidation under alkaline conditions. The nickel centers in the Ni-TMAF facilitate efficient electron transfer and redox reactions, leading to the high sensitivity of 203.89 μA μM –1 cm –2 and lower LOD of 0.33 μM and fast response time of <3 s in glucose sensors. Their stability, cost-effectiveness, and high performance make 3D Ni-TMAF a promising material for nonenzymatic electrochemical glucose sensors.