MAIT cell activation is associated with disease severity markers in acute hantavirus infection
Kimia T. Maleki, Johanna Tauriainen, Marina García, Priscilla F. Kerkman, Wanda Christ, Joana Dias, Julia Wigren Byström, Edwin Leeansyah, Mattias N.E. Forsell, Hans‐Gustaf Ljunggren, Clas Ahlm, Niklas K. Björkström, Johan K. Sandberg, Jonas Klingström
Abstract
activation of MAIT cells by hantavirus-exposed antigen-presenting cells is dependent on type I interferons (IFNs) and independent of interleukin-18 (IL-18). These findings highlight the role of type I IFNs in virus-driven MAIT cell activation and suggest a potential role of MAIT cells in the disease pathogenesis of viral infections.
Topics & Concepts
HantavirusImmunologyHantavirus InfectionBiologyVirologyCytokine stormPathogenesisPuumala virusDiseaseAntigenT cellVirusMedicineImmune systemInfectious disease (medical specialty)PathologyCoronavirus disease 2019 (COVID-19)Viral Infections and VectorsViral Infections and Outbreaks ResearchImmune Cell Function and Interaction