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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Ziming Wang, Ethan G. Aguilar, Jesus I. Luna, Cordelia Dunai, Lam T. Khuat, Catherine T. Le, Annie Mirsoian, Christine M. Minnar, Kevin Stoffel, Ian R. Sturgill, Steven K. Grossenbacher, Sita S. Withers, Robert B. Rebhun, Dennis J. Hartigan-O’Connor, Gema Méndez‐Lagares, Alice F. Tarantal, R. Rivkah Isseroff, Thomas S. Griffith, Kurt A. Schalper, Alexander A. Merleev, Asim Saha, Emanual Maverakis, Karen Kelly, Raid Aljumaily, Sami Ibrahimi, Sarbajit Mukherjee, Michael Machiorlatti, Sara K. Vesely, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, William J. Murphy, Arta M. Monjazeb

2018Nature Medicine847 citationsDOI

Topics & Concepts

BlockadeMedicineImmunotherapyCancerImmune systemCancer immunotherapyImmune checkpointObesityTumor microenvironmentLeptinOncologyTumor progressionInternal medicineBiomarkerImmunologyBiologyReceptorBiochemistryAdipokines, Inflammation, and Metabolic DiseasesDietary Effects on HealthCancer Immunotherapy and Biomarkers
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade | Litcius