Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones
Lisa Zuily, Nora Lahrach, Rosi Fassler, Olivier Genest, Peter Faller, Olivier Sénèque, Yann Denis, Marie‐Pierre Castanié‐Cornet, Pierre Genevaux, Ursula Jakob, Dana Reichmann, Marie‐Thérèse Giudici‐Orticoni, Marianne Ilbert
Abstract
With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular mechanisms by which copper causes cell death are not yet fully understood.
Topics & Concepts
AntimicrobialCopperChemistryDrugAntibiotic resistanceAntibioticsMicrobiologyPharmacologyBiologyBiochemistryOrganic chemistryTrace Elements in HealthComputational Drug Discovery MethodsIron Metabolism and Disorders