Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis
Laiyi Xu, Wenzhou Zhang, Juan Francisco Sánchez-Tejeda, Denys Holovan, Julia McCain, Terri C. Lovell, Gonzalo Cosa
Topics & Concepts
ChemistryEndoplasmic reticulumLipid peroxidationAntioxidantMitochondrionGPX4BiochemistryCell biologyApoptosisLipid dropletReactive oxygen speciesProgrammed cell deathSubcellular localizationCellLipid oxidationBiophysicsCrosstalkFluorescenceCell survivalLipid metabolismOxidative stressFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsRedox biology and oxidative stress