Discovery of 4’-trifluoromethylchalcones as novel, potent and selective hCYP1B1 inhibitors without concomitant AhR activation
Yue Wu, Jinhui Shi, Guanghao Zhu, Yuan Xiong, Jia-Hao Gong, Huizhen Wei, Zhao-Bin Guo, Ziru Dai, Xiao-Bo Sun, Guang‐Bo Ge
Topics & Concepts
ChemistryChalconeIC50StereochemistryDocking (animal)TrifluoromethylEnzymeAntagonistStructure–activity relationshipPharmacologyBiochemistryIn vitroReceptorAlkylNursingOrganic chemistryMedicinePharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsInflammatory mediators and NSAID effects