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Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium

Nuno G. Alves, Inês Bártolo, Américo J. S. Alves, Diana Fontinha, Denise Francisco, Susana M. M. Lopes, Maria I. L. Soares, Carlos J. V. Simões, Miguel Prudêncio, Nuno Taveira, Teresa M. V. D. Pinho e Melo

2021European Journal of Medicinal Chemistry34 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIn vitroPlasmodium falciparumAntimicrobialStructure–activity relationshipStereochemistryBiological activityHuman immunodeficiency virus (HIV)LactamMoleculeCombinatorial chemistryBiochemistryMalariaVirologyBiologyImmunologyOrganic chemistrySynthesis of β-Lactam CompoundsSynthesis and Catalytic ReactionsMetal complexes synthesis and properties
Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium | Litcius