Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids
Waleed Rahmani, Hyunjae Chung, Sarthak Sinha, Maxwell P. Bui-Marinos, Rohit Arora, Arzina Jaffer, Jennifer A. Corcoran, Jeff Biernaskie, Justin Chun
Abstract
) known to restrict viral entry, and attenuated the infection of proximal tubule cells by SARS-CoV-2. Our work highlights the susceptibility of proximal tubule cells to SARS-CoV-2 and reveals a putative protective role for RAS inhibitors during SARS-CoV-2 infection.
Topics & Concepts
KidneyVirologyTropismBiologyRenin–angiotensin systemImmunologyMedicineVirusEndocrinologyBlood pressureCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchOptimism, Hope, and Well-being