Iron-Catalyzed C–C Single-Bond Cleavage of Alcohols
Wei Liu, Qiang Wu, Miao Wang, Yahao Huang, Peng Hu
Abstract
An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.
Topics & Concepts
ChemistryHomolysisCatalysisBond cleavageCleavage (geology)Primary (astronomy)ChlorineTertiary alcoholsAlcohol oxidationPhotocatalysisPhotochemistryOrganic chemistryCombinatorial chemistryMedicinal chemistryRadicalPhysicsFracture (geology)AstronomyGeotechnical engineeringEngineeringCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsAsymmetric Hydrogenation and Catalysis