Polycystic Ovarian Syndrome Genetics and Epigenetics
JOSHUA C. COMBS, MICAH J. HILL, ALAN H. DECHERNEY
Abstract
Polycystic ovarian syndrome and its associated endocrine abnormalities comprise one of the most common metabolic spectrum disorders within the human race. Because of the variance in phenotypic expression among individuals and within family lineages, attention has been turned to genetic and epigenetic changes in which the root cause of the disorder may lie. Further understanding of DNA/histone methylation and microRNA patterns may help to improve the accuracy of diagnosis and lead to future treatment options.
Topics & Concepts
EpigeneticsmicroRNAPolycystic ovaryDNA methylationBioinformaticsBiologyGeneticsEndocrine systemPhenotypeMedicineHuman geneticsGenetic disorderEpigenesisGenetic variantsGenetic variationMethylationHeredityBroad spectrumDiseaseMetabolic disorderInternal medicineMutationGenetic linkageOvarian function and disordersGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesBiological Research and Disease Studies