Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function
Jiajia Li, Qingchao Li, Lingyi Zhang, Songling Zhang, Yun Dai
Abstract
Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the treatment of female cancer patients with BRCA mutations, including younger patients. However, the impact of PARPi on ovarian function remains a considerable problem in clinical practice. In this review article, we summarize the current understanding of PARPi's effects on the function of ovary and discuss their potential underlying mechanisms, highlighting the significance of further investigation on the criterion for ovarian failure and its preventive approaches during PARPi treatment.
Topics & Concepts
Poly ADP ribose polymerasePolymeraseOvarian cancerCancer researchMedicineDNA repairBiologyCancerBioinformaticsGeneticsInternal medicineDNAPARP inhibition in cancer therapyOvarian cancer diagnosis and treatmentReproductive Biology and Fertility