Visible-Light-Induced Four-Component Ritter-Type Reaction: Access to β-Trifluoromethyl Imides
Ransong Ma, Yuanyuan Ren, Zhoubin Deng, Ke‐Hu Wang, Junjiao Wang, Danfeng Huang, Xiaobo Lv, Yulai Hu
Abstract
A visible-light-induced four-component Ritter-type reaction was developed for the synthesis of β-trifluoromethyl imides from CF 3 Br, alkenes, carboxylic acids, and nitriles. This protocol features mild reaction conditions, a broad substrate scope, and excellent functional group compatibility. Furthermore, this method has been proven to be suitable for the late-stage diversification of drug molecules. A mechanism involving a Ritter-type reaction and Mumm rearrangement was proposed on the basis of the control experiments.
Topics & Concepts
ChemistryRitter reactionTrifluoromethylImideCombinatorial chemistryVisible spectrumPhotochemistryOrganic chemistryCatalysisOptoelectronicsAlkylPhysicsFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions