DNA-compatible functional group transformations <i>via</i> K<sub>2</sub>RuO<sub>4</sub>-mediated oxidation
Pengyang He, Guixian Zhao, Mengping Zhu, Yangfeng Li, Gong Zhang, Yizhou Li
Abstract
K 2 RuO 4 -mediated oxidation offers a DNA-compatible method for functional group transformations, enabling alcohol-to-carboxylic acid and amine-to-nitrile conversions valuable for DNA-encoded library synthesis.
Topics & Concepts
ChemistryNitrileFunctional groupDNAAmine gas treatingGroup (periodic table)Combinatorial chemistryAlcoholStereochemistryOrganic chemistryBiochemistryPolymerChemical Synthesis and AnalysisCarbohydrate Chemistry and SynthesisSynthesis and Catalytic Reactions