Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application
Zhen Wang, Chuanzhen Huang, Jun Wang, Bin Zou, Ch Asad Abbas, Xiaodan Wang
Abstract
In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.
Topics & Concepts
StereolithographyBioceramicMaterials scienceScaffoldCancellous boneBiomedical engineeringTissue engineeringCeramicComposite materialAnatomyEngineeringMedicineBone Tissue Engineering MaterialsAdditive Manufacturing and 3D Printing Technologies3D Printing in Biomedical Research