Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration
Jing Niu, Hudagula Bai, Zizhou Li, Y Gao, Yan Zhang, Xiyuan Wang, Yaxi Yang, Yungen Xu, Meiyu Geng, Zuoquan Xie, Bing Zhou
Topics & Concepts
StingStimulator of interferon genesAgonistChemistryPharmacologySignal transductionInterferonGene isoformSystemic administrationCancer researchInnate immune systemMedicineImmunologyReceptorIn vivoBiochemistryBiologyGeneAerospace engineeringEngineeringBiotechnologyinterferon and immune responsesViral Infections and VectorsImmune Response and Inflammation