Squamins C–F, four cyclopeptides from the seeds of Annona globiflora
Javier Sosa-Rueda, Vanihamin Domínguez-Meléndez, Araceli Ortiz-Celiseo, Fernando C. López-Fentanes, Cristina Cuadrado, José J. Fernández, Antonio Hernández Daranas, Francisco Cen‐Pacheco
Abstract
Four cyclic octapeptides, squamins C-F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie.