Carrier Solvents of Electronic Nicotine Delivery Systems Alter Pulmonary Surfactant
Nathalie Hayeck, Carl Zoghzoghi, Ebrahim Karam, Rola Salman, Nareg Karaoghlanian, Alan Shihadeh, Thomas Eissenberg, Salah Zein El Dine, Najat A. Saliba
Abstract
-glycero-3-phosphocholine (DPPC). The interaction of DPPC and PG-VG is studied by attenuated total reflectance fourier transform infrared spectroscopy. The results showed that PG and VG altered the molecular alignment of the DPPC surfactant. The orientation of the surfactant at the surface of the lung affects the surface tension at the air-water interface, thereby influencing breathing. These findings suggest that chronic aerosolization of the primary solvents in ENDS might alter the function of pulmonary surfactant.
Topics & Concepts
Pulmonary surfactantChemistryAttenuated total reflectionAerosolizationInhalationLungSurface tensionOrganic chemistryInfrared spectroscopyBiochemistryAnesthesiaMedicineInternal medicinePhysicsQuantum mechanicsInhalation and Respiratory Drug DeliveryNeuroscience of respiration and sleepNeonatal Respiratory Health Research