Nano-purpurin-Cu delivery via TPGS-induced macropinocytosis enables cuproptosis/metabolic synergy to ablate cancer stemness and Boost immunotherapy in colorectal cancer
Yunfeng Song, Wenting Cheng, Hailong Tian, Yi‐Chun Huang, Yichun Huang, Yongfeng Jia, Li Xu, Li Xu
Topics & Concepts
Cancer researchImmunogenic cell deathImmunotherapyTumor microenvironmentPhotodynamic therapyColorectal cancerImmune systemCancerNanocarriersCancer immunotherapyCancer cellMetastasisPinocytosisDendritic cellMedicineCellReprogrammingCell metabolismDrug deliveryBiologyGlutamineCell therapyGlutaminolysisImmunosurveillanceIntracellularPD-L1T cellNanoplatforms for cancer theranosticsCancer Research and TreatmentsCancer, Hypoxia, and Metabolism