Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models
Hashi Akter, Md. Mamunur Rashid, Md. Shahidul Islam, Md. Amjad Hossen, Md. Atiar Rahman, Reham M. Algheshairy, Mona S. Almujaydil, Hend F. Alharbi, Afnan M. Alnajeebi
Abstract
This research investigated the cardioprotective effects of Tamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention in Swiss albino models. The results were verified by in silico interactions of GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. TIEx showed an excellent antioxidative effect and a significant (P < 0.05) decrease in C-reactive protein (CRP), Serum troponin I (STI), aspartate transaminase (AST), lactate dehydrogenase (LDH), and creatinine kinase-MB (CKMB), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) in treatment groups in comparison with standard drug valsartan. The selected bioactive compounds especially Thymine, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- showed the highest binding affinity with the human AT1 receptor antagonist complexed with PPARγ agonist. Results demonstrate that Tamarindus indica parts could be a food supplement for cardiac toxicity.