Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods
Shibin Mathew, David A. Tess, Woodrow Burchett, George Chang, Nathaniel A. Woody, Christopher Keefer, Christine C. Orozco, Jian Lin, Samantha Jordan, Shinji Yamazaki, Rhys D.O. Jones, Li Di
Topics & Concepts
Physiologically based pharmacokinetic modellingIn silicoIn vivoQuantitative structure–activity relationshipPartition coefficientPharmacokineticsChemistryBiological systemVolume of distributionPharmacologyComputational biologyChromatographyBiologyBiochemistryStereochemistryBiotechnologyGeneComputational Drug Discovery MethodsDrug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism